Education
- Ph.D., Chemical Engineering. Rice University. 1995
- Dip. Eng., Chemical Engineering. National Technical
University of Athens, Greece. 1989
Research Interests
The vascular system represents an exquisite feat of
bioengineering. Fluid (blood) flow and mass transfer are intimately
integrated with and actively regulate vascular cell responses.
Elucidating the molecular nature of cellular processes in the dynamic
setting of the vasculature therefore requires the synthesis of
engineering principles with quantitative modeling, and concepts from
biochemistry and molecular cell biology. My research in Molecular and
Cellular Bioengineering is directed at developing a mechanistic
understanding of the effects of shear stress due to fluid flow on gene
regulation and receptor-mediated cell-cell interactions pertinent to
cancer metastasis and inflammation/infection, two of the most critical
pathological processes affecting mankind. The ultimate goal of my
research program is to develop molecular therapies to combat these
disorders using a directed multi-disciplinary approach.
Publications
- S.L. Napier, Z.R. Healy, R.L. Schnaar,
K. Konstantopoulos, "Selectin Ligand Expression Regulates the
Initial Vascular Interactions of Colon Carcinoma Cells: The Roles of
CD44v and Alternate Sialofucosylated Selectin Ligands",
Journal of Biological Chemistry 282(6);
3433-3441, 2007.
- Z.R. Healy, N.H. Lee, M. Goldring, P. Talalay, T.W.
Kensler, and K. Konstantopoulos, "Divergent
Responses of Chondrocytes and Endothelial Cells to Shear Stress:
Cross-talk among COX-2, the Phase 2 Response and Apoptosis",
Proceedings of the National Academy of Sciences USA
102(39); 14010-14015, 2005.
- S. Jadhav, C.D. Eggleton, and K.
Konstantopoulos, "A 3D Computational Model Predicts that Cell
Deformation Affects Receptor-Ligand Bond Lifetime and the Number of
Bonds During Rolling Under Shear", Biophysical Journal
88(1); 96-104, 2005.
- W.D. Hanley, D. Wirtz, K. Konstantopoulos,
"Distinct Kinetic and Mechanical Properties Govern Selectin-Leukocyte
Interactions", Journal of Cell Science
117(12); 2503-2511, 2004.
- P. Pawar, P.K. Shin, S.A. Mousa, J.M. Ross, and
K. Konstantopoulos, "Fluid Shear Regulates the Kinetics and
Receptor Specificity of Staphylococcus Aureus
Binding to Activated Platelets", Journal of Immunology
173(2); 1258-1265, 2004.
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