Our lab focuses on areas related to cellular, metabolic and biochemical engineering. The goal is to optimize cell lines to produce high quality and quantity of proteins of biopharmaceutical interest.
The CELL CYCLE ENGINEERING group focuses on cell cycle and the inhibition of programmed cell death (apoptosis) using combinatorial genetic strategies. By blocking certain metabolic pathways which initiate the apoptosis program, we have been able to delay cell death in model bioreactor environments and have shown increased protein production.
The GLYCO-ENGINEERING group focuses on the metabolic engineering of insect cells to produce glycoproteins with profiles similar to mammalian cells, thereby making it an ideal host for production of therapeutics and antibodies.